Hemodinâmica renal e efeitos diuréticos da baixa dose de dopamina em gatos anestesiados / Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats

Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats

1. James S. Wohl DVM, Diplomate ACVIM, ACVECC¹, 
2. Dean D. Schwartz PhD², 
3. W. Shannon Flournoy DVM, MS¹, 
4. Terrence P. Clark DVM, PhD, Diplomate ACVCP⁴,
5. James C. Wright DVM, PhD, Diplomate ACVPM³

Article first published online: 26 JAN 2007

DOI: 10.1111/j.1476-4431.2006.00209.x

Issue

Journal of Veterinary Emergency and Critical Care

Volume 17, Issue 1, pages 45–52, March 2007

Additional Information(Show All)

Keywords:

• diuresis;
• dopaminergic;
• feline;
• renal protection;
• urine output

Abstract

Objective: To evaluate the effects of low-dosage (3 μg/kg/min) dopamine on urine output, renal blood flow, creatinine clearance, sodium excretion, heart rate, and mean arterial pressure (MAP) in healthy anesthetized cats.

Design: Controlled experimental study.

Setting: University experimental laboratory.

Animals: Twelve random-bred 2–4-year-old cats.

Interventions: Anesthesia, laparotomy for renal artery blood flow measurement, and arterial and venous catheterization.

Measurements: Heart rate (HR), MAP, renal blood flow, urine output, sodium excretion, fractional sodium excretion, and creatinine clearance.

Main results: No significant difference in urine output, sodium excretion, HR, or creatinine clearance occurred in cats receiving low-dosage dopamine. A transient decrease in the mean arterial blood pressure occurred in cats receiving dopamine.

Conclusions: Low-dosage dopamine cannot be expected to induce diuresis in healthy cats. Low-dosage dopamine may cause vasodilation in non-renal vascular beds.