Saturday, April 13, 2013

Hemodinâmica renal e efeitos diuréticos da baixa dose de dopamina em gatos anestesiados / Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats


Renal hemodynamic and diuretic effects of low-dosage dopamine in anesthetized cats

  1. James S. Wohl DVM, Diplomate ACVIM, ACVECC1
  2. Dean D. Schwartz PhD2
  3. W. Shannon Flournoy DVM, MS1
  4. Terrence P. Clark DVM, PhD, Diplomate ACVCP4,
  5. James C. Wright DVM, PhD, Diplomate ACVPM3
Article first published online: 26 JAN 2007
DOI: 10.1111/j.1476-4431.2006.00209.x
Journal of Veterinary Emergency and Critical Care

Journal of Veterinary Emergency and Critical Care

Volume 17Issue 1pages 45–52March 2007

Keywords:

  • diuresis;
  • dopaminergic;
  • feline;
  • renal protection;
  • urine output

Abstract

Objective: To evaluate the effects of low-dosage (3 μg/kg/min) dopamine on urine output, renal blood flow, creatinine clearance, sodium excretion, heart rate, and mean arterial pressure (MAP) in healthy anesthetized cats.
Design: Controlled experimental study.
Setting: University experimental laboratory.
Animals: Twelve random-bred 2–4-year-old cats.
Interventions: Anesthesia, laparotomy for renal artery blood flow measurement, and arterial and venous catheterization.
Measurements: Heart rate (HR), MAP, renal blood flow, urine output, sodium excretion, fractional sodium excretion, and creatinine clearance.
Main results: No significant difference in urine output, sodium excretion, HR, or creatinine clearance occurred in cats receiving low-dosage dopamine. A transient decrease in the mean arterial blood pressure occurred in cats receiving dopamine.
Conclusions: Low-dosage dopamine cannot be expected to induce diuresis in healthy cats. Low-dosage dopamine may cause vasodilation in non-renal vascular beds.

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